KSIĄŻKI POWIĄZANE ZE SŁOWEM «HIRUDIN»
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1
Plants as Factories for Protein Production - Halaman 62
secreted in the salivary glands of the medicinal leech, Hirudo medicinalis. Hirudin is a powerful anticoagulant with a number of very desirahle properties including stoichiometric inhibition of thrombin, short clearing time from the blood and low ...
Elizabeth E. Hood, J.A. Howard, 2013
2
Transgenic Plants: A Production System for Industrial and ...
oil bodies from transgenic seeds with antihirudin monoclonal antibodies, followed by cross-reaction with secondary antibodies fused to fluorescein, shows the presence of hirudin on the oil body surface. The reduction in fluorescence observed ...
Meran R. L. Owen, Jan Pen, 1996
3
Heparin-Induced Thrombocytopenia, Fourth Edition - Halaman 345
HIRUDIN AND ITS DERIVATIVES A. Chemistry Hirudin, the most potent natural thrombin inhibitor identified to date, is a 65amino-acid polypeptide (molecular mass, approximately 7 kDa) produced by the parapharyngeal glands of the ...
Theodore E. Warkentin, Andreas Greinacher, 2007
4
Textbook of Coronary Thrombosis and Thrombolysis - Halaman 627
Restricting the analysis to clinical endpoints, the rate of in-hospital death or reinfarction in the hirudin group was 6.8% compared with 16.7% in the heparin group (P = 0.02). Finally, in the hirudin group there was a trend toward less reocclusion ...
5
Hemostasis and Thrombosis: Basic Principles and Clinical ...
The a-thrombin-hirudin complex. A: The a-carbon backbone structure of thrombin (light bluei and the a-carbon backbone structure of hirudin (redi. Disulfide bonds in the NH,-terminal domain of the hirudin molecule are in yellow, and "insertion ...
6
The Design of Synthetic Inhibitors of Thrombin - Halaman 196
was now produced in different biological systems and expressed in bacteria (E. coli) or yeast cells (S. cerevisiae), through which it had become posssible to provide sufficient quantities of hirudin and hence the therapeutical use of the ...
Goran Claeson, Michael F. Scully, Vijay V. Kakkar, 2013
7
Serine Proteases and Their Serpin Inhibitors in the ... - Halaman 116
Hirudin Hirudin is a polypeptide inhibitor of thrombin that can be isolated from the salivary gland of the medicinal leech Hirudo medicinalis. The anticoagulant activity in the saliva of leech was first described by Haycraft in 1884.” A polypeptide ...
8
Fibrinogen, Thrombosis, Coagulation, and Fibrinolysis - Halaman 178
identified by Chang (22) who showed that treatment of hirudin with S. aureus Vs proteinase or carboxypeptidase Y, both treatments leading to removal of C-terminal structural elements, leads to significant loss of inhibitory activity. Bajusz et al.
Chung Yuan Liu, S. Chien, 2012
9
Handbook of Proteolytic Enzymes - Halaman 2926
... with hirudin fragment, N-(carboxymethyl)-3-cyclohexyl-D-alanyl-N-(4carbamimidoyl-1,3-thiazol-2-yl)methyl]-L-prolinamide inhibited o-thrombin; complex with hirudin fragment; N-[(2R,3S)-3-amino-2-hydroxy-4-phenyl-butyl]-4methoxy-2,3 ...
Alan J. Barrett, Neil D. Rawlings, J. Fred Woessner, 2012
10
Textbook of Interventional Cardiovascular Pharmacology - Halaman 100
Fatal anaphylaxis has been reported in patients who received a repeat intravenous bolus administration of lepirudin after an interval of a few months (49). Since hirudin is excreted by the kidneys, dose reduction and careful monitoring are ...
Nicolas Kipshidze, Jawad Fareed, Patrick W. Serruys, 2007
