КНИГИ НА МАЛАЙСКИЙ ЯЗЫКЕ, ИМЕЮЩЕЕ ОТНОШЕНИЕ К СЛОВУ «TACI»
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National Institute of Allergy and Infectious Diseases, ... - Halaman 346
C104 is located in the second CRD of TACI and forms disulfide bonds with the C93 stabilizing the second h2 loop of CRD2 (16). The C104R mutation was demonstrated to abolish binding of APRIL and BAFF to TACI (48, 49). In the majority of ...
Vassil St. Georgiev, Karl Western, John J. McGowan, 2008
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BLyS Ligands and Receptors - Halaman 117
that only the second CRD of TACI is important for ligand binding [3]. Indeed, alternative splicing of TACI in humans produces a shorter protein (“TACI short”) lacking the first CRD, which binds to ligands with similar affinities as full length TACI.
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B Cell Biology in Autoimmunity - Halaman 33
A soluble form of the BLyS receptor, TACI-Fc, was first used in the treatment of lupus in the NZB/W F1 and MRL-lpr/lpr mouse models of this disease [11]. Although only a modest reduction was achieved in the serum levels of anti-dsDNA ...
David Ahmad Nemazee, 2003
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Death Receptors and Cognate Ligands in Cancer - Halaman 164
It has been suggested that TACI has a specific requirement for oligomerised ligands (Bossen et al. 2008). Since BAFF was crystallised as both a trimer and also a higher multimeric form, which reportedly occurs physiologically, it may be that ...
5
Primary Immunodeficiency Diseases: Definition, Diagnosis, ...
The functional activity of TACI is, however, ambiguous: while TACI-deficient mice predominantly develop autoimmunity and lym- phoproliferation, TACI deficiency in humans primarily manifests itself as an antibody deficiency syndrome, ...
Nima Rezaei, Asghar Aghamohammadi, Luigi D. Notarangelo, 2008
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Molecular Biology of B Cells - Halaman 255
The role of BAFF-R on activated T cells appears to be to promote Bcl2 expression and T helper-1 (Th1) cytokine production in effector CD4 T cells [27]. The role of BAFF-R on regulatory T cells remains unclear. Mouse TACI is expressed most ...
Tasuku Honjo, Michael Reth, Andreas Radbruch, 2014
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Deadly Politics: A Taci Andrews Mystery
Investigative reporter Taci Andrews is back in this explosive third book of the Deadly series.
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Advances in Immunology - Jilid 111 - Halaman 67
5.3. TACI. mutations. TACI (encoded by TNFRSF13B) belongs to the tumor necrosis factor receptor superfamily and is found on B cells (Schneider, 2005). Other members of this group include the molecules B cell activating factor receptor ...
Taci remained in her bedtherest of theday. All the fuzzeeps met in the central cavern and discussed the situation, but since they had always given the princess everything she had asked for, noone had any good ideas onwhat needed tobedone ...
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Chronic Lymphocytic Leukemia: New Research - Halaman 245
Nevertheless, transgenic mice for soluble BCMA neutralising APRIL but not BAFF do not present modification in B compartments. This suggests a crucial role of BAFF interacting with TACI (or BAFF-R), whereas BCMA and APRIL should not be ...
