与 «OSTEOCLAST»相关的英语书籍
在以下的参考文献中发现
osteoclast的用法。与
osteoclast相关的书籍以及同一来源的简短摘要提供其在 英语文献中的使用情境。
1
New Paradigm: Survival Pathway Promotion of
Osteoclast Survival
Understanding the complex interactions of Transforming Growth Factor-beta (TGF-beta) in the bone environment during bone development, normal bone remodeling and during conditions of excessive bone loss such as tumor driven osteolysis and ...
Anne Margaret Gingery, 2007
2
Physiopathology of
Osteoclast in Bone
Bone is constantly remodeled by osteoclastic bone resorption and osteoblastic bone formation.
Proposed sites of action of cytokines on osteoclast differentiation and activation.
Interleukin (ID-1, tumor necrosis factor (TNF)-oc, IL- 15, IL-17, and parathyroid
hormone-related peptide (PTHrP) enhance osteoclast formation by stimulating
the ...
E. William St. Clair, David S. Pisetsky, Barton F. Haynes, 2004
4
Cell Apoptotic Signalling Pathways
The cessation of bone resorption precedes bone formation, and is characterized
by osteoclast apoptosis. Although apoptosis has been studied in rodent models
of osteoclast differentiation, little is known about osteoclast apoptosis in humans.
5
Biology and Physiology of the
Osteoclast
The book features some of the latest work (much of which has never before been published) from internationally respected scientists in the field.
Barry R. Rifkin, Carol V. Gay, 1992
6
Dynamics of Bone and Cartilage Metabolism: Principles and ...
treatment with IL-6 and its soluble receptor (sIL-6R) induced osteoclast formation,
but when added separately they were ineffective [26]. The other cytokines in this
group, IL-11, leukemia inhibitory factor (LIF), and oncostatin M (OSM), all of ...
Markus J. Seibel, Simon P. Robins, John P. Bilezikian, 2006
7
Bone Remodelling and its Disorders
The early pre-osteoclast contains nonspecific esterase but not tartrate-resistant
acid phosphatase according to the observations of Baron et al (1986). Based on
in vitro data with long-term marrow cultures (Roodman et al 1985; Takahashi et al
...
8
Fundamentals of Osteoporosis
The osteoclast then secretes acid via H+-ATPase (for hydroxyapatite dissolution)
and proteases including cathepsin K (for matrix protein digestion) into this closed
microcompartment along the bone surface referred to as the hemivacuole, ...
Robert Marcus, David Feldman, Dorothy Nelson, 2009
9
Bone Research Protocols
11. Osteoclast. Formation. in. the. Mouse. Coculture. Assay. Robert J. van 'tHof 1.
Introduction The murine coculture assay originally described by Takahashi et al. (
1), was the first culture system developed that generated genuine, ...
Miep H. Helfrich, Stuart Ralston, 2003
10
Osteoporosis: Two-Volume Set
The early differentiation stages of osteoclast formation depend on the
transcription factor PU.1, which regulates c-fms expression along with the
transcription factor src [53,54]. The expression of c-fms, the macrophage colony-
stimulating factor ...
Robert Marcus, David Feldman, David W. Dempster, 2013
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Klein-Nulend et al. Mechanical stress, estrogen and osteocytes …
... microarchitecture provide new insights into the mechanosensitivity of osteocytes and their orchestration of osteoclast and osteoblast activity. «Nature.com, 七月 15»
RANKL Signaling Pathway in Oncology Drug Pipeline Update 2015
It binds to Receptor activator of NF-kB (RANK) and plays a major role in the regulation of osteoclast function. Binding of RANKL to RANK leads ... «PR Newswire, 七月 15»
Prostate And chest Cancer; New Treatment Options
If metastatic bone disease is present, then treatment with bisphosphonates or osteoclast inhibitors will often be added. These palliative ... «Information Nigeria, 七月 15»
Targeting the Pim kinases in multiple myeloma
... al. p38 MAPK in myeloma cells regulates osteoclast and osteoblast activity and induces bone destruction. Cancer Res 2012; 72: 6393–6402. «Nature.com, 七月 15»
Multiple Myeloma Hides in Bones Like a Wolf in Sheep's Clothing
... such as bone-forming osteoblasts and osteocytes, and the bone-resorbing osteoclast cells. These changes make the multiple myeloma cells ... «Newswise, 七月 15»
FTY720 inhibited proinflammatory cytokine release and …
In addition, S1P signaling regulated the migration of osteoclast precursors and affected osteoclastogenesis. Furthermore, treatment with ... «7thSpace Interactive, 七月 15»
LOX does some prepping
Drugs that prevent osteoclast-mediated bone resorption — such as bisphosphonates and the RANKL-specific monoclonal antibody ... «Nature.com, 七月 15»
Effects of eldecalcitol on cortical bone response to mechanical …
Eldecalcitol inhibits in vitro osteoclast formation through suppression of c-Fos protein expression in osteoclast precursor cells. Vitamin D also ... «BMC Blogs Network, 六月 15»
DNA methylation by Dnmt3a regulates osteoclastogenesis
Their genome-wide screen for mRNAs expressed in osteoclast precursors (bone marrow-derived monocyte-macrophage precursor cells) ... «Nature.com, 六月 15»
A microRNA code for prostate cancer metastasis
Tumor cell homing into the bone marrow promotes dramatic alterations in osteoblast and osteoclast function and bone remodeling, causing ... «Nature.com, 六月 15»
