10 ENGLISH BOOKS RELATING TO «DICUMAROL»
Discover the use of
dicumarol in the following bibliographical selection. Books relating to
dicumarol and brief extracts from same to provide context of its use in English literature.
1
Pharmaceutical Achievers: The Human Face of Pharmaceutical ...
This hemorrhagic agent — 3,3'-methylene bis-(4-hydroxycoumarin) — was later
named "dicumarol." Dicumarol is formed naturally when coumarin oxidizes and
combines with other substances present in moldy hay. Link also demonstrated ...
Mary Ellen Bowden, Amy Beth Crow, Tracy Sullivan, 2003
2
Blackwell's Five-Minute Veterinary Consult: Equine
When cut and baled for hay under high-moisture conditions, various molds
metabolize coumarin to form dicumarol, which inhibits vitamin K epoxide
reductase, in turn decreasing vitamin K] formation and leading to decreased
prothrombin ...
Jean-Pierre Lavoie, Kenneth Hinchcliff, 2011
3
2010 Nurse's Drug Handbook
dicumarol. Class and Category Chemical class: Coumarin derivative Therapeutic
class: Anticoagulant Pregnancy category: X Indications and Dosages ® To
prevent and treat pulmonary embolus, thromboembolus, and venous thrombus; ...
& Bartlett Jones, Jones and Bartlett Publishers, 2009
If PT or INR are prolonged, withhold one dicumarol dose, as prescribed, and, to
reverse anticoagulation, give vitamin K. If patient has severe bleeding, expect to
give blood to offset vitamin K's delayed onset. • Assess patient for signs of ...
Jones and Bartlett Publishers, 2008
5
Drug Interactions in Psychiatry
No consistent effect on warfarin elimination was observed. A similar protocol was
followed with dicumarol, 200 mg and 300 mg doses. Inconsistent effects were
observed on dicumarol metabolism, with a suggestion that dicumarol absorption
...
Its analysis showed it to be dicumarol, a compound that results when a coumarin
molecule is linked to another coumarin molecule by an enzyme present in the
fungus that causes hay mold. The requirement of the fungal enzyme for this ...
Stanley Fields, Mark Johnston, 2010
7
Veterinary Pharmacology and Therapeutics
Dicumarol is hydroxylated by hepatic enzymes to inactive compounds that are
excreted in urine; the metabolites have no anticoagulant effect. Variations in rate
of metabolism are due in part to genetic factors. A small quantity, if any, appears ...
Jim E. Riviere, Mark G. Papich, 2013
8
Applied Pharmacokinetics & Pharmacodynamics: Principles of ...
O O = CH, OH Nature 4-Hydroxycoumarin Warfarin Figure 28-1 Synthesis
pathways for the coumarin anticoagulants, dicumarol and warfarin. Dicumarol
was first isolated from spoiled sweet clover. Warfarin is a synthetic compound
initially ...
Routine for Administration of Dicumarol Determine the prothrombin time each
day before ordering the dose of Dicumarol for that day. The exact dose of
Dicumarol on any given day will depend upon the patient's responsiveness to the
drug ...
University of California, San Francisco Medical Center, 1949
10
Oxidative Stress in Cancer Biology and Therapy
The effects of streptonigrin were reversed in pancreatic cancer cells pretreated
with dicumarol, a known inhibitor of NQO1. Another potential strategy to exploit in
pancreatic cancer is the fact that cancer cells demonstrate increased intracellular
...
Douglas R. Spitz, Kenneth J. Dornfeld, Koyamangalath Krishnan, 2011
6 NEWS ITEMS WHICH INCLUDE THE TERM «DICUMAROL»
Find out what the national and international press are talking about and how the term
dicumarol is used in the context of the following news items.
To Your Good Health: Medicines from nature have long, effective …
Researchers at the University of Wisconsin later identified dicumarol in the clover as the substance that blocked the production of clotting ... «Columbus Dispatch, Jun 15»
Is Aspirin a Dangerous Drug?
About 1941, Huebner and Link of the Wisconsin Agricultural Experimental Station discovered that dicumarol when given by mouth induces a ... «JAMA: The Journal of the American Medical Association, Dec 14»
Sweet clovers
“The toxic factor is dicumarol, which is formed from coumarin only when the sweet clover is spoiled by certain kinds of mold. Poisoning is more ... «Michigan State University Extension, Jul 13»
How dead cattle led to the discovery of warfarin
In the article 'The Discovery of Dicumarol and Its Sequels' for the American Heart Association journal Circulation, the chemist Dr Karl Paul Link ... «PMLiVE, Jun 13»
Farmer, sick herd and persistent UW scientist results in warfarin
Based on this knowledge, they developed a drug called Dicumarol that was tested by doctors in St. Paul and elsewhere to see if it could ... «Pioneer Press, Oct 11»
Innovation marks UW-Madison contribution to vitamins, drugs …
In 1941, Karl Paul Link discovered dicumarol, an anti-coagulant and poison. From dicumarol, Link synthesized coumadin (Warfarin), the first ... «University of Wisconsin-Madison, Jul 11»
