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These discoveries of allotypy and individual antigenic specificity completely laid
to rest the notion that serum proteins (or, indeed, any proteins) of individual
members of a species were necessarily identical. Equally important, and more ...
2
New Methods of Automated Analysis of Protein Structures
... C region or on a portion of the V region that is invariant within the chains of
each allotype but is distinct for each allotype. Differences in the amino acid
sequences of the constant regions of the light chains have been correlated with
allotypy.
3
Isoantigenicity of human plasma proteins
Allotypy Starting from his studies on rabbit gamma globulin groups Oudin [310]
created the term of allotypy. In 1962 Dray, Dubisky, Kelus, Lennox and Oudin [
108] published a 'notation for allotypy', in which appears the following definition: ...
4
The Network Collective: Rise and Fall of a Scientific Paradigm
The phenomenon was termed “allotypy”,from the Greek (different) and (type).
Allotypy was found also for human16 and mouse immunoglobulin genes17 and
was for many years the main, if not the only way to study the genetics of antibody
...
5
The Variation and Adaptive Expression of Antibodies
129:141. Oudin, J. (1960a). "Allotypy of rabbit serum proteins. I. Immuno-
chemical analysis leading to the individualization of seven main allo- types," /.
Exp. Med. 1 1 2: 1 07. (1960b). "Allotypy of rabbit serum proteins. II. Relationships
between ...
6
PROG NUCLEIC ACID RES&MOLECULAR BIO
It is conceivable, if the number of substitutions is not large, that this could be
accomplished by a few tRNA molecules that may conceivably exist in antibody-
forming cells for the sole purpose of specifying allotypy (of course, they would be
found ...
James Norman Davidson, Waldo E. Cohn,
1973
7
Human Immunogenetics: Basic Principles and Clinical Relevance
Both allotypy and deficiency of factor H have been noted (16,77). 4. C4b-Binding
Protein The C4b-binding protein (C4-bp) is a 550,000-MW glycoprotein. It is
composed of seven to eight disulfide-linked chains of 70,000 MW each (22,78,79
).
8
Further Milestones in Biochemistry
Allotypy of rabbit serum proteins. I. Immunochemical analysis leading to the
individualization of seven main allotypes. J. Exp. Med. 112, 107-124. Oudin, J . (
1960b). Allotypy of rabbit serum proteins. II. Relationships between various
allotypes: ...
M.G. Ord, L.A. Stocken,
1997
9
Molecular biology, biochemistry and biophysics
The allotypy of rabbit immunoglobulins has been intensely studied and our
knowledge of its molecular basis and genetics is now considerable. The subject
has recently been reviewed (Oudin, 1968; Gell and Kelus, 1967). Our knowledge
of ...
CHAINS: ALLOTYPY AND SEQUENCE Investigators: Michael D. Waterfield,
Marianne Wright, Leroy E. Hood Support: National Institutes of Health, Public
Health Service National Science Foundation One of the most puzzling
phenomena ...