与 «HYPOMORPHIC»相关的英语书籍
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1
Characterization of a Murine
Hypomorphic Allele of the ...
Bub1 is a serine/threonine kinase originally described as a core component of the spindle assembly checkpoint (SAC) mechanism in yeast.
Mark Jason Schliekelman, 2008
2
Principles of Regenerative Biology
Among the invertebrates, hypomorphic regeneration is frequently seen in
regenerating insect limbs. The proper interpretation of hypomorphic regeneration
is not always easy, because hypomorphism can be due to causes as diverse as ...
3
Hypomorphic Ribonucleotide Reductase Alleles are ...
This work reports two alleles of RNR1 (S269P and S610F) that are synthetically lethal with the loss of MMR in haploid S. cerevisiae .
Expression of the hypomorphic target allele can be activated by Cre-mediated
removal of the floxed neo gene. Because this activation can be performed in mice
heterozygous or homozygous for the hypomorphic alleles, it can be also used for
...
5
The Genome of Drosophila melanogaster
The dlstal portlon of the first tarsal segment 1nc1ud1ng the .1“ X “Y Kaufman 1“"
Sgeramre'sens"“'e sex comb in males is fused directly to the proximal pore . . . . ,
8b3 EMS Fomili lab/7 hypomorphic allele tron of the femur. Thus proxrmal first ...
Dan L. Lindsley, Georgianna G. Zimm, 1992
6
LATIN '92: 1st Latin American Symposium on Theoretical ...
G and G' are said to be doubly m-hypomorphic if there exists a bijection a : V — »
w such that for any W C V with #W = m, (G(W,j),G(W^4>)) ~ (G'(a(WO,<£),G'(a(HO,
-<£)). Such a is called a double m-hypomorphism (or simply a double ...
7
Clinical Immunology,Principles and Practice (Expert Consult ...
Hypomorphic. mutations. in. JAK3. Brugnoni, et al. described an infant with JAK3
mutations that affected but did not abolish JAK3 protein expression and function.
By 3months of age, the patient had circulating autologous CD3þCD4þ T cells, ...
Robert R. Rich, Thomas A. Fleisher, William T. Shearer, 2013
8
Genetic Analysis: Genes, Genomes, and Networks in Eukaryotes
If on the other hand, the m/deletion strain has a more severely mutant phenotype
than the m/m strain, then m is not behaving like the deletion and m must have
some amount of residual wild-type function. m is then defined to be a
hypomorphic ...
9
The Cardiac Lymphatic System: An Overview
Careful analyses of the mice with a hypomorphic Tiel allele reveal that Tiel is
involved in the remodeling and stabilization of lymphatic vessels [52]. In these
mice, the expression level of Tiel is reduced. The phenotype of these mice
reveals a ...
10
Phosphoinositide 3-kinase in Health and Disease: Volume 1
That idea was proven right when PDK1 hypomorphic mice expressing reduced
levels of PDK1 were obtained and were shown to be viable. These mice
exhibited no overt phenotype other than being smaller because of a reduction in
cell size ...
Christian Rommel, Bart Vanhaesebroeck, Peter K. Vogt, 2010
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Systems biology surveillance decrypts pathological transcriptome …
Further data for the critical cardiogenic role of Pitx2 have been reported in models that express hypomorphic Pitx2, which caused ... «BMC Blogs Network, 七月 15»
Mice with reduced Myc function are healthier and live longer
However, the Myc hypomorphic phenotype did not appear to have any effect on the age-associated increase in DNA damage due to oxidative ... «Nature.com, 六月 15»
TP53: an oncogene in disguise
Although many hotspot TP53 mutations are transcriptionally inactive, the majority of the remaining TP53 missense variants are hypomorphic, ... «Nature.com, 五月 15»
Experts Discuss Managing Hereditary Colorectal Cancer Syndromes
According to Dr. Boland, the two most common mutations in the MutYH gene for whites are a very inactive allele and a hypomorphic allele. The interaction ... «General Surgery News, 五月 15»
Are all the previously reported genetic variants in limb girdle …
On the other hand, the interpretation of our results is complicated by additional genetic mechanisms, such as hypomorphic and low penetrant ... «Nature.com, 四月 15»
LPA signaling initiates schizophrenia-like brain and behavioral …
Conversely, a 'hypomorphic' outcome, which would not induce gross hydrocephalus but still affect the developing brain, might be produced by ... «Nature.com, 四月 15»
Cellular STAT3 Functions via PCBP2 To Restrain Epstein-Barr Virus …
Using Burkitt lymphoma cells and EBV+ cell lines from patients with hypomorphic STAT3 mutations, we demonstrate that single cells ... «Journal of Virology, 四月 15»
Prolonged access to thymic epithelial MHCI seals CD8 + lineage …
Interestingly, this uncoupling partially blocks T-cell development at a later stage than the partial block caused by the hypomorphic Zap70SKG ... «Nature.com, 三月 15»
Fruit Flies Shed Light on Diabetic Mysteries
"These data suggest that the human NMU R165W mutation represents a hypomorphic loss-of-function allele and that impaired regulation of ... «MedPage Today, 二月 15»
Students from Kansas, Oklahoma honored for research at …
Everett Hall, graduate student from Wildwood, Missouri, in anatomy and cell biology, “Compound mouse mutants of Specc1l hypomorphic ... «KU Today, 二月 15»
