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B lymphoblastic leukaemia/lymphoma with hypodiploidy This is an uncommon
form of B-lineage ALL (1–5% of cases). Hypodiploidy can be further categorized
as near haploidy (23–29 chromosomes), low hypodiploidy (33–39 chromosomes
) ...
2
Molecular Pathology of Hematolymphoid Diseases
... 17 conferred the best outcome.68 According to the current COG risk
stratification, in the absence of unfavorable features, patients with these three
trisomies are assigned to the low-standard risk treatment group.8 Hypodiploidy
Hypodiploidy, ...
Cherie H. Dunphy, Philip T. Cagle, 2010
3
Postgraduate Haematology
... MLL rearrangement or hypodiploidy <44 chromosomes; MRD <1% at day 15 or
remission induction and <0.01% at the end of 6-week remission induction
Standard T-cell phenotype (except ETP ALL) and B-cell precursor cases not
classified ...
A. Victor Hoffbrand, Daniel Catovsky, Edward G. D. Tuddenham, 2011
4
Cancer Cytogenetics: Chromosomal and Molecular Genetic ...
Hypodiploidy, defined aslessthan 46chromosomes, is rare inALL.It occurs atan
overall incidence of approximately 5%, independently of age (Harrisonet al.,2004
). Based on chromosome number and characteristic cytogenetic features, ...
Sverre Heim, Felix Mitelman, 2011
... but under 1% having fewer than 44 chromosomes (which include three distinct
groups: near-haploidy [24-31 chromosomes, 57% of cases], low-hypodiploidy [32
-39 chromosomes, 34% of cases], and high-hypodiploidy [40-43 chromosomes, ...
6
Hematologic Malignancies: Acute Leukemias
The class-defining genes on chromosome X were overexpressed irrespective of
whether the leukemic blasts had an extra copy of this chromosome [28]. It is
unclear what mechanism leads to this pattern. 6.4.2 Hypodiploidy Hypodiploidy is
...
Elihu H. Estey, S.H. Faderl, H.M. Kantarjian, 2007
7
Myeloma Therapy: Pursuing the Plasma Cell
A Model with Hypoploidy and B2M In a French study that identified hypodiploidy
as a significant poor prognostic factor, a prognostic model including hypodiploidy
and B2M was proposed. The low-risk group without hypodiploidy and with low ...
8
Mechanisms of Oncogenesis: An update on Tumorigenesis
6.5.7.4 Hypodiploidy and Near-Haploidy Hypodiploidy (≤45 chromosomes),
representing a heterogeneous subgroup of patients, is found in ∼8% of cases of
childhood ALL. Hypodiploidy has been further divided as near-haploid (23–29 ...
9
Atlas of Peripheral Blood: The Primary Diagnostic Tool
The resulting overexpression of interleukin-3 presumably drives the
nonneoplastic eosinophil proliferation. The prognosis of this rare disorder is
unclear. B-ALL with hyperdiploidy and B-ALL with hypodiploidy are distinct
categories of B-ALL in ...
Irma Pereira, Tracy I. George, Daniel A. Arber, 2011
10
Childhood Leukemia: A Practical Handbook
In contrast, hypodiploidy portends a poor outcome. Hypodiploidy occurs in 6–9%
of childhood ALL cases, with the vast majority having 45 chromosomes.
Approximately 1% of children with ALL have extreme hypodiploidy, which is
defined as ...
Gregory H. Reaman, Franklin O. Smith, 2011
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hypodiploidy在以下新条目的上下文中是如何使用的。
TRAIL-receptor preferences in pancreatic cancer cells revisited …
Twenty-four hours later apoptosis was measured by DNA hypodiploidy assays. Furthermore, the specificities of the sTRAIL variants were ... «7thSpace Interactive, 七月 15»
U.S. swimmers support Mesa teen with leukemia
The condition, known as hypodiploidy, significantly reduces the cure rate to 30 percent without a bone-marrow transplant. "His older sister and ... «azcentral.com, 八月 14»
Toddler's family asking for prayers as she battles deadly form of …
... is asking community members to add the child to their prayer lists as she battles Acute Lymphoblastic Leukemia with Hypodiploidy (ALL). «Your Houston News, 十二月 12»
Management Strategies in Acute Lymphoblastic Leukemia
Survival in certain subgroups, such as infants and cases with adverse genetic features (eg, hypodiploidy), has improved very little over time. «Cancer Network, 四月 11»
Therapeutic considerations in managing multiple myeloma
... recommend that all patients diagnosed with MM be screened for DNA hypodiploidy, immunoglobulin heavy chain (IgH) translocations (ie, t[4; ... «Modern Medicine, 七月 09»
Multiple Myeloma
... patients with karyotypic deletion of chromosome 13 or hypodiploidy, the t(4;14) or t(14;16) translocation, or a plasma cell–labeling index of 3 ... «New England Journal of Medicine, 十月 04»