10 ENGLISH BOOKS RELATING TO «SPHINGOSINE»
Discover the use of
sphingosine in the following bibliographical selection. Books relating to
sphingosine and brief extracts from same to provide context of its use in English literature.
1
Different Approaches of Teaching in Chemistry. Membrane ...
Mattie, M., Brooker, G., Spiegel, S.: Sphingosine-l-phospate, a putative second
messenger, mobilizes calcium from internal stores via an inositol trisphosphate-
independent pathway. J. Biol. Chem. 269 (5): 3181-8, 1994. 12. Lee, M. J. ...
2
IKACh and
Sphingosine 1-phosphate Signaling in the Heart
Sphingosine-1 -phosphate (SIP) is a product of sphingomyelin metabolism that
binds with nanomolar affinity to five members of a family of G protein coupled
receptors (S 1 P1-5) [160, 161]. SIP has been implicated in cell proliferation, ...
Maria Isabel Roman Alonso, 2006
3
Sphingolipids as Signaling and Regulatory Molecules
(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with
the activation of p38 mitogen-activated protein kinase and is abrogated by
sphingosine kinase 1. Mol Cancer Res 2007; 5:801-812. 41. Sankala HM, Hait
NC, ...
Charles Chalfant, Maurizio Del Poeta, 2011
4
Sphingosine 1-phosphate Receptor 2 in Vascular Homeostasis
Chapter III Sphingosine 1 -phosphate receptor 2 promotes atherosclerosis
through caspase-11 inflammasome component 3.1.1 Atherogenesis
Atherosclerosis a major human disease that contributes to 77 Sphingosine 1-
phosphate receptor 2 ...
5
Part I: Discovery of
Sphingosine 1-phosphate Receptor Type-1 ...
Abstract Part 1 Sphingosine-1-phosphate (S1P) is a signaling lipid molecule
which acts both as an intracellular mediator and an extracellular ligand for
specific cell surface receptors to regulate cellular condition and physiological
processes.
6
Lipid Mediators and Their Metabolism in the Brain
Sphingosine is an 18-carbon amino alcohol with an unsaturated hydrocarbon
chain. It is found in sphingolipids (cerbroside, sulfatide, and ganglioside) as well
as phospholipid (sphingomyelin) (Fig. 9.1). Sphingomyelin (SM) is the major ...
acyl chain (at any desired position in the molecule) as well as carbons 1-3 of the
sphingosine base, which form the interfacial region of the sphingomyelin
molecules in bilayers and lipoproteins (see sections 4a, 4b). The complete
chemical ...
John Nigel Hawthorne, 1982
8
General, Organic, and Biological Chemistry
The double bond present in the sphingosine carbon chain is a trans double bond
. When sphingolipids were discovered over a century ago by the physician–
chemist Johann Thudichum (1829–1901), their biochemical role seemed as ...
9
TEXTBOOK OF BIOCHEMISTRY AND HUMAN BIOLOGY
A. Biosynthesis of Sphingosine The initial step in the biosynthesis of glycolipids is
the formation of sphingosine. Earlier work from various laboratories has shown
that one of the precursors of sphingosine is serine and the other is palmitic acid.
G. P. TALWAR, L .M. SRIVASTAVA, 2002
10
Encyclopedia of Molecular Pharmacology
Deficiency of either SphKl or SphK2 in mice does not cause obvious
abnormalities, while double knockout mice die during embryogenesis. These
data suggest that despite opposing functions the two sphingosine kinase
isoenzymes can ...
10 NEWS ITEMS WHICH INCLUDE THE TERM «SPHINGOSINE»
Find out what the national and international press are talking about and how the term
sphingosine is used in the context of the following news items.
Cortisone affects acute lung injury (ALI) via pro-inflammatory …
In the case of ALI, dexamethasone leads to an increase of sphingosine-1-phosphate and, consequently, to a strengthening of the vessel walls' barrier function. «Medical Xpress, Jul 15»
Celgene Buys Receptos. Is Arena Pharmaceuticals Next?
Sphingosine 1-phosphate 1, or S1P1, receptor is expressed on white blood cells, also called lymphocytes, and signaling of the receptor by S1P promotes the ... «Motley Fool, Jul 15»
Lipid Enzyme Heightens Insulin Sensitivity and Shows Promise as …
Excess ceramide was converted into sphingosine, another lipid byproduct. Both ceramide and sphingosine are energy sources, but the two lipids have contrary ... «Newswise, Jul 15»
RedHill Biopharma Initiates Phase I/II Study of ABC294640 for …
SK2 is an innovative molecular target for anti-cancer therapy because of its critical role in catalyzing the formation of the lipid-signaling molecule sphingosine ... «Nasdaq, Jun 15»
Sphingosine 1-Phosphate Type 1 (S1P-1) Receptor Agonists …
DelveInsight's, Sphingosine 1-Phosphate Type 1 (S1P-1) Receptor Agonists- Pipeline Insights, 2015, provides the in-depth analysis of the pipeline assets ... «PR Newswire, Jun 15»
Akaal Pharma Receives Approval to Initiate Phase 2 Clinical Trial for …
AKP-11 is a novel First-in-Class topical Sphingosine 1-Phosphate receptor-1 (S1P1) modulator for the treatment of mild-to-moderate plaque psoriasis in patients ... «Business Wire, Jun 15»
Receptos Announces Oral Plenary Presentation of TOUCHSTONE …
Ozanimod is a novel, oral, once daily, selective sphingosine 1-phosphate 1 and 5 receptor modulator in development for autoimmune indications including ... «GlobeNewswire, May 15»
RedHill Biopharma Acquires Phase II First-in-Class Oral Small …
ABC294640 is a proprietary, first-in-class, orally-administered sphingosine kinase-2 (SK2) inhibitor, with anti-inflammatory and anti-cancer activities, targeting ... «GlobeNewswire, Mar 15»
Akaal Pharma Announces Positive Results from Phase 1 Clinical …
AKP-11 is a novel, potent and highly selective sphingosine 1-phosphate receptor subtype-1 (S1P1) modulator undergoing clinical development for topical ... «VentureBeat, Feb 15»
Arena's APD334 Has Real Blockbuster Potential (ARNA)
APD334, sphingosine 1-phosphate (S1P) subtype 1 receptor modulator, is safer than the only approved S1P product, Gilenya. It also displayed impressive ... «Seeking Alpha, Jan 15»
