O QUE SIGNIFICA MELPHALAN EM INGLÊS
Melphalan
O melphalan é um fármaco de quimioterapia pertencente à classe de agentes alquilantes de mostarda de nitrogênio. Um agente de alquilação adiciona um grupo alquilo ao DNA. Ele atribui o grupo alquilo à base de guanina do DNA, no átomo de nitrogênio do número 7 do anel de imidazol. Caso contrário, conhecido como L-Phenylalanine Mustard, ou L-PAM, o melfalan é um derivado de fenilalanina da mecloretamina.
definição de melphalan no dicionário inglês
A definição de melphalan no dicionário é um medicamento, C13H18Cl2N2O2, usado para tratar a leucemia mielóide.
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10 LIVROS EM INGLÊS RELACIONADOS COM «MELPHALAN»
Descubra o uso de
melphalan na seguinte seleção bibliográfica. Livros relacionados com
melphalan e pequenos extratos deles para contextualizar o seu uso na literatura.
1
Principles and Practice of Gynecologic Oncology
It is known chemically as 4-[bis(2-chloroethyl)amino]-L-phenylalanine. Melphalan
is water insoluble and previously was only commercially available in a 2-mg
tablet form. However, a parenteral formulation was approved by the FDA in 1993.
2
The Chemotherapy Source Book
Melphalan has been reported to cause HSRs primarily when administered
intravenously (185,186). Oral melphalan has produced only a rare instance of
reaction, whereas i.v. melphalan (despite concurrent prednisone administration)
...
Michael Clinton Perry,
2008
3
Thomas' Hematopoietic Cell Transplantation
Modulation of cytostatic efficacy of melphalan by glutathione: mechanisms and
efficacy. Chem Biol Interact 2002; 140: 93–107. 175. Schecter RL, Woo A, Duong
M, Batist G. In vivo and in vitro mechanisms of drug resistance in a rat mammary ...
Frederick R. Appelbaum, Stephen J. Forman, Robert S. Negrin,
2011
4
Principles and Practice of Gynecologic Oncology
Melphalan Chemistry. Melphalan (Alkeran, L-phenylalanine mustard, L-PAM) is a
phenylalanine derivative of nitrogen mustard that acts as a bifunctional alkylating
agent. Melphalan is FDA approved for the chemotherapy of patients with ...
Richard R. Barakat, Maurie Markman, Marcus Randall,
2009
5
Blood and Marrow Stem Cell Transplantation: Principles, ...
Melphalan. Pharmacology Melphalan is a bifunctional alkylating agent with
significant activity against multiple myeloma. Melphalan also exhibits high single-
agent activity against testicular and ovarian carcinoma as well as certain
sarcomas.
Marie Bakitas Whedon, Debra Wujcik,
1997
6
Multiple Myeloma: Translational and Emerging Therapies
This exciting new text, edited by lauded authorities on the topic, stands as the only available reference to assemble, review, and synthesizes the latest studies on translational therapies and clearly explains the impact of molecular ...
Kenneth C. Anderson, M. Ghobrial Irene,
2007
7
The AARP Guide to Pills: Essential Information on More Than ...
What are melphalan tablets? MELPHALAN (Alkeran® ) is a type of chemotherapy
for treating cancer. Melphalan interferes with cell growth and treats cancers of the
ovaries and bone marrow. Generic melphalan tablets are not yet available.
MaryAnne Hochadel, Jerry Avorn,
2007
8
Blood and Marrow Stem Cell Transplantation: Principles, ...
Melphalan, an alkylating agent, is a derivative of nitrogen mustard. Although
myelosuppres- sion is the most common side effect, anorexia, nausea, vomiting,
stomatitis, hemorrhagic cystitis, and transaminitis may occur acutely. Melphalan (
150 ...
Susan Ezzone, Kim Schmit-Pokorny,
2007
9
Malignant Liver Tumors: Current and Emerging Therapies
Regional delivery of high dose melphalan has been demonstrated to be safe and
effective in stage IV disease confi ned to the liver for several different types of
cancer. Experience has demonstrated that IHP using melphalan alone or in ...
Pierre-Alain Clavien,
2011
10
Regional Therapeutics for Advanced Malignancies
00 C O .5 U G) (I) Table 1 Regimen, response rates and response assessment
method for published series of isolated limb perfusion in sarcoma 9 N C/PD 0%
64% Hill (1993)36 TNF + Melphalan 100% 0% Clinical Santinami (1996)” TNF +
...
10 NOTÍCIAS NAS QUAIS SE INCLUI O TERMO «MELPHALAN»
Conheça de que se fala nos meios de comunicação nacionais e internacionais e como se utiliza o termo
melphalan no contexto das seguintes notícias.
Delcath Announces Pricing Of Public Offering
Our proprietary Melphalan Hydrochloride for Injection for use with the Delcath Hepatic Delivery System (Melphalan/HDS) is designed to ... «PharmiWeb.com, jul 15»
Roth Affirms Ligand Pharma (LGND) at 'Buy'; Promacta Q2 Revenue …
CE-Melphalan's (Evomela) PDUFA date is October 23, 2015. Internally, we believe a key driver will be from LGD-6972 (glucagon receptor ... «StreetInsider.com, jul 15»
Momentum Stocks- Exelixis, Inc. (NASDAQ:EXEL), Delcath Systems …
... of Orphan Products Development or OOPD has decided Orphan Drug Designation for melphalan for the treatment of cholangiocarcinoma. «StreetWise Report, jul 15»
Stocks In Momentum- The Boeing Company (NYSE:BA), Lockheed …
... of Orphan Products Development or OOPD has decided Orphan Drug Designation for melphalan for the treatment of cholangiocarcinoma. «StreetWise Report, jul 15»
FDA grants orphan drug designation to melphalan for … - Healio
The FDA granted orphan drug designation to melphalan for the treatment of patients with cholangiocarcinoma, according to a press release ... «Healio, jul 15»
CASI Pharmaceuticals (CASI) Brings ZEVALIN to Hong Kong
In addition to ZEVALIN, the Company has exclusive marketing rights in greater China to MARQIBO® and EVOMELA™ (CE-Melphalan HCl) for ... «StreetInsider.com, jul 15»
Adaptimmune Therapeutics (ADAP) Announces Publication of T …
After autologous stem cell collection, patients were conditioned with high-dose melphalan followed two days later by autologous stem cell ... «StreetInsider.com, jul 15»
Thalidomide As Effective As Lenalidomide in Combo Regimen for …
Overall response rates, progression-free survival, and overall survival are similar when comparing melphalan, prednisone, thalidomide ... «Cancer Therapy Advisor, jul 15»
Adaptimmune's NY-ESO-1 TCR-engineered T-Cells Demonstrate …
After autologous stem cell collection, patients were conditioned with high-dose melphalan followed two days later by autologous stem cell ... «PharmiWeb.com, jul 15»
Donor-derived constitutional chromosomal abnormalities after …
Preparative regimens were either busulfan/fludarabine or fludarabine/melphalan. Two patients received myeloablative preparative regimens. «Nature.com, jul 15»